Meta-Analysis of Adverse Events- Cervarix, September 4, 2007

To: Mr. Matthew Whitman
 File: STN 125259/0 CERVARIX
 RE: Meta-Analysis of Adverse Events
 Date: September 4, 2007


 Regarding your submission to the BLA dated Aug. 27, 2007, we request that you provide an analysis for testing the homogeneity of relative risks among the studies in the Level 2 analyses. In your response, please include the statistical analysis plan and the results.
